Tadalafilo 20mg: What You Need to Know
Guía de Salud Masculina
Tadalafil 20mg is a drug used to treat erectile dysfunction (ED) and pulmonary arterial hypertension (PAH).
1. Treatment of erectile dysfunction (ED)
1、mechanism of action
- Tadalafil belongs to a phosphodiesterase type 5 (PDE5) inhibitor. During male erection, sexual stimulation causes the corpus cavernosum to release nitric oxide (NO). NO activates guanylate cyclase and increases the level of cyclic guanosine phosphate (cGMP), which leads to relaxation of smooth muscles and blood flows into the corpus cavernosum to cause erection. PDE5 degrades cGMP. Tadalafil inhibits PDE5 and increases the level of cGMP, which helps maintain the erectile function of the penis.
2、use method
- When taken as needed, it can generally be taken within about 30 minutes to 12 hours before sexual activity. However, it should be noted that sexual stimulation must be used after taking. You can also follow a regular taking plan, such as a small daily dose. Take it to obtain a more stable effect.
3、precautions
- Tadalafil should not be used simultaneously with nitrates (such as nitroglycerin), as combination of the two may cause severe hypotension.
- Patients with cardiovascular disease should use it with caution and consult a doctor and conduct a comprehensive evaluation before use, because erectile dysfunction may be an early warning sign of cardiovascular disease and the drug may have certain effects on the cardiovascular system.
2. Treatment of pulmonary arterial hypertension (PAH)
1、mechanism of action
- In patients with pulmonary arterial hypertension, tadalafil inhibits PDE5, increases cGMP content in pulmonary vascular smooth muscle cells, causes pulmonary vascular relaxation, and reduces pulmonary vascular resistance, thereby reducing the right ventricular overload and improving patient symptoms and exercise ability.
2、use method
- For the treatment of pulmonary hypertension, it is usually necessary to take the dose prescribed by the doctor regularly every day.
3、precautions
- It may cause some adverse reactions, such as headache, facial flushing, indigestion, etc. During treatment, patients need to undergo regular assessments, including symptom assessment, cardiac function assessment (such as echocardiography, etc.), and blood tests (such as liver function, etc.) to monitor the efficacy and safety of the drug.